Assay of lercanidipine hydrochloride in dosage forms using nucleophilic substitution reaction
نویسندگان
چکیده
منابع مشابه
Assay of lercanidipine hydrochloride in dosage forms using nucleophilic substitution reaction.
A simple and sensitive spectrophotometric method has been developed for the assay of lercanidipine hydrochloride (LER) in bulk and in formulations. The method is based on the formation of coloured species between the drug and 1,2-naphthaquinone-4-sulphonic acid sodium salt (NQS) by means of nucleophilic substitution reaction. Absorbance was measured at λ(max) = 460 nm. The method was analyzed s...
متن کاملStability Indicating UV-Spectrophotometric Assay Of Terbinafine Hydrochloride In Dosage Forms
Two sensitive, precise and cost-effective UV-spectrophotometric methods are described for the determination of terbinafine hydrochloride (TFH) in bulk drug and tablets. The methods are based on the measurement of absorbance of TFH in 0.1M HCl at 222 nm in method A and in 0.1M acetic acid at 282 nm in method B. As per the International Conference on harmonization ICH guidelines, the methods were...
متن کاملVoltammetric behavior of lercanidipine and anodic adsorptive stripping voltammetric method for assay in pharmaceutical dosage forms and biological fluids
Electrochemistry of lercanidipine (LCN) was investigated and its optimal conditions were evaluated based on the irreversible and diffusion-controlled electrochemical oxidation signal (+ 0.93 V) of a carbon paste electrode (CPE) versus Ag/AgCl in Britton Robinson buffer (BR) and ethanol mixture of pH 4.5. Electrochemical determination was performed by square wave anodic adsorptive stripping volt...
متن کاملDetermination of pKa’s of hydroxamic acids by nucleophilic substitution reaction
Acid dissociation constant (pKa) of some para-substituted benzohydroxamic, 4-XC6H4CONHOH, and N-methyl parasubstituted benzohydroxamic acids, 4XC6H4CON(OH)CH3, where X = H, CH3, CH3O, NO2, Cl, have been determined spectrophotometrically by nucleophilic substitution reactions of pnitrophenyl acetate with hydroxamate ions at 27± 0.1C. All reactions in this study follow pseudo-first order kinetics...
متن کاملDynamic origin of the stereoselectivity of a nucleophilic substitution reaction.
A nucleophilic substitution on a dichlorovinyl ketone was studied experimentally and computationally. A mixture of products is observed experimentally, but a conventional computational analysis does not account for the formation of the minor stereoisomer. Instead, the product mixture is predicted accurately from a dynamic trajectory study on a bifurcating energy surface. The dynamic origin of t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Pharmaceutica
سال: 2011
ISSN: 1846-9558,1330-0075
DOI: 10.2478/v10007-011-0031-5